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KMID : 0358619750090020023
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Korean Journal of Physiology
1975 Volume.9 No. 2 p.23 ~ p.31
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Effects of Ethanol on the Cardiovascular Respones to Electrical Stimulation of Vagus Nerve and the Hypothalamus
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Abstract
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The effects of ethanol intravenously administered on the mean arterial blood pressure and heart rate responses to electrical stimulation of vagus nerve and the hypothalamus were studied in the cats. Also investigated were the effects of ethanol on the cardiovascular responses to .bilateral carotid occlusion and t intravenously injected epinephrine and acetylcholine separately.
The results obtained from the present study were as follows;
1. In 1.0 ml/kg and 2.0 ml/kg of ethanol infused groups the mean arterial blood pressure increased gradually and reached plateaus in 10 minutes after ethanol infusion while no marked changes in blood pressure were observed in 0. 5 ml/kg of ethanol infused group.
2. The pressor responses elicited by the electrical stimulation . of the hypothalamus were ,depressed directly proportionally to amount of ethanol infused. In 0.5 ml/kg of ethanol infused .group the pressor response was reduced to 84.5% of control value and it declined to 17.0% of control in 2.0 ml/kg of ethanol infused group.
3. After ethanol administration the heart rate decreased slightly and also was decreased positive chronotropic effect elicited by hypothalamic stimulation. In several cases even negative chronotropic responses were observed during electrical stimulation in the hypothalamus.
4. Since the pressor responses to bilateral carotid occlusion was reduced by ethanol administration it is suggested that activity of baroreceptor is inhibited by ethanol.
5. No changes were observed in the negative chronotropic effect produced by eletrical stimulation of the vegus nerve of ethanol infused animal. And cardiovascular responses to intravenously injected epinephrine and acetylcholine were not influenced by ethanol either.
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